EstroGel-Estradiol Gel for Estrogen Replacement Therapy
 
EstroGel-Estradiol Gel for Estrogen Replacement Therapy
EstroGel-Estradiol Gel for Estrogen Replacement Therapy Evolution of Estrogen Therapy
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Menopause symptom relief
Benefits of EstroGel

EstroGel has been clinically proven to provide relief from common menopause symptoms, such as hot flashes and vaginal dryness and itching.1,2
While the physical symptoms of menopause may be bearable, the interruption of your daily activities may not be. It’s important for you to discuss your symptoms with your doctor and decide what therapy works best for you.

EstroGel may be an option for you. EstroGel has been shown in clinical studies to manage common menopause symptoms so that you can continue your active lifestyle.1,2 You’ve worked too hard to put everything on hold now.

EstroGel relieves menopause symptoms.1,2
• Clinically proven to reduce vasomotor symptoms, such as hot flashes, associated with menopause1
• Used to relieve vaginal dryness and itching1

EstroGel is proven to reduce the frequency of hot flashes.2*
• In a clinical study, EstroGel was shown to reduce frequency of moderate to severe hot flashes by 73% after 6 weeks of treatment, compared with a nonmedicated gel2

73% reduction in menopause hot flash frequency

In a multicenter, randomized, double-blind, placebo-controlled study, patients (N=145) were randomly assigned to 2 therapy arms.1,2 The primary efficacy outcome measure was the change from baseline in the frequency of moderate to severe hot flashes at week 12.2 Mean baseline frequency was approximately 10 to 11 hot flashes per day.
*Data based on last observation carried forward.
†P<0.05 vs placebo.

EstroGel is clinically proven to decrease the severity of hot flashes.2*
• After 4 weeks of EstroGel use, menopausal women showed a 98% greater reduction in the severity of moderate to severe hot flashes compared with women being treated with a nonmedicated gel2

98% greater reduction in menopause hot flash severity

In a multicenter, randomized, double-blind, placebo-controlled study, patients (N=145) were randomly assigned to 2 therapy arms.1,2 Severity was rated as 0 (none), 1 (mild),
2 (moderate), or 3 (severe).2 Baseline severity score was 2.30 (±0.24) for placebo and 2.36 (±0.29) for EstroGel.
*Data based on last observation carried forward.

EstroGel relieves vaginal dryness and irritation associated with menopause.1
• Relieves vaginal dryness and irritation1
• Helps relieve the discomfort associated with painful sexual intercourse1
• Therapy is not vaginally delivered1

EstroGel has been shown to be safe when used as directed.1
• In a clinical study, EstroGel very rarely irritated the skin1
- Less than 1% incidence of application-site reaction reported1
• Relief is delivered in a low dose of estrogen, as recommended by top women’s health organizations1

Like all medications, discuss the proper use and administration of EstroGel with your doctor before you begin using it.
 
 

IMPORTANT SAFETY INFORMATION

EstroGel is indicated in the treatment of moderate to severe vasomotor symptoms associated with menopause and in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy associated with menopause. When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered.

Estrogens increase the chances of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using EstroGel. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots.

Do not use estrogens with or without progestins to prevent dementia. Using estrogens with or without progestins may increase your risk of dementia.

EstroGel should not be used if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, currently have or have had liver problems, are allergic to EstroGel or any of its ingredients, think you may be pregnant, or if you are breastfeeding.

The most commonly reported adverse events of estrogens include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss.

You and your healthcare provider should talk regularly about whether you still need treatment with EstroGel.

Please see full patient information (PDF).

REFERENCES: 1. EstroGel 0.06% [package insert]. Herndon, VA: ASCEND Therapeutics, Inc; 2006. 2. Archer DF for the EstroGel Study Group. Percutaneous 17ß-estradiol gel for the treatment of vasomotor symptoms in postmenopausal women. Menopause. 2003;10:516-521.

This web site is intended for U.S. residents only.
EstroGel® is a registered trademark of LaSalle Laboratories, Inc. ©2007 ASCEND Therapeutics, Inc. All Rights Reserved.

 
     
   
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