How to Use EstroGel

EstroGel is a modern, bioidentical option for managing some of your menopausal symptoms and is ideal for women with active lifestyles. 

EstroGel is the only non-patch transdermal estrogen therapy that provides relief of both moderate to severe hot flashes and moderate to severe vaginal dryness, itching, and burning after menopause.1

  • It’s a gel that’s applied to one arm, once a day1
  • EstroGel dries quickly and is odorless when dry1
  • After EstroGel dries, lotion may be applied2
  • It’s a discreet therapy, so no one knows you’re treating your symptoms

 Once-daily dosing1

  • Before using the pump for the first time, it must be primed. Remove the large pump cover, and fully depress the pump twice for the 93-gram pump or 3 times for the 50-gram pump and the 25-gram pump. Discard the unused gel by thoroughly rinsing down the sink or placing it in the household trash. After priming, the pump is ready to use, and one complete pump depression will dispense the same amount of EstroGel each time.
  • Apply EstroGel at the same time each day. You should apply your daily dose of gel to clean, dry, unbroken skin. If you take a bath or shower or use a sauna, apply your EstroGel dose after your bath, shower, or sauna. If you go swimming, try to leave as much time as possible between applying your EstroGel dose and going swimming.

  • Be sure your skin is completely dry before applying EstroGel.

  • To apply the dose, collect the gel into the palm of your hand by pressing the pump firmly and fully once. Apply the gel to the skin of one arm using your hand. Spread the gel as thinly as possible over the entire area on the inside and outside of your arm from wrist to shoulder.
  • Always place the small protective cap back on the tip of the pump and the large pump cover over the top of the pump after each use.
  • Wash your hands with soap and water after applying the gel to reduce the chance that the medicine will spread from your hands to other people.

  • It is not necessary to massage or rub in EstroGel. Simply allow the gel to dry for up to 5 minutes before dressing. Once dry, EstroGel is odorless. Alcohol-based gels are flammable. Avoid fire, flame or smoking until the gel has dried.

  • Never apply EstroGel directly to the breast. Do not allow others to apply the gel for you.


EstroGel® 0.06% is approved by the FDA for use after menopause to reduce moderate to severe hot flashes and to treat moderate to severe menopausal changes in and around the vagina. If you use EstroGel only to treat your menopausal changes in and around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you.


  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using EstroGel.  Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb).  Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
  • Using estrogen-alone may increase your chances of getting strokes and blood clots.
  • Using estrogen-alone may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Do not use estrogens with progestins to prevent heart disease, heart attack, strokes or dementia.
  • Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
  • Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • You and your healthcare provider should talk regularly about whether you still need treatment with EstroGel.

Do not start using EstroGel if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack, currently have or have had blood clots, currently have or have had liver problems, have been diagnosed with a bleeding disorder, are allergic to EstroGel or any of its ingredients, or think you may be pregnant.

Tell your healthcare provider if you have any unusual vaginal bleeding, have any other medical conditions, are going to have surgery or will be on bed rest, are breastfeeding, and about all the medicines you take.

Serious but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus (womb), cancer of the ovary, high blood pressure, high blood glucose, gallbladder disease, liver problems, changes in your thyroid hormone levels, and enlargement of benign tumors (“fibroids”).

Common side effects of estrogens include headache, breast pain, stomach or abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection.

If you would like more information, talk with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

  1. EstroGel 0.06% (estradiol gel) [package insert]. Herndon, VA: ASCEND Therapeutics; 2014.
  2. Data on file, ASCEND Therapeutics.