Important Risk Information
Prescribing Information
Patient Information

How to Use EstroGel

One pump, on one arm, once a day1

How to Use EstroGel

One pump, on one arm, once a day1

Click for EstroGel Patient Information, including Instructions for Use.

Watch a video demonstration.

Priming the EstroGel Pump

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Before using the EstroGel pump for the first time, the pump must be primed.

The EstroGel canister contains enough medicine to allow you to prime the pump before you use it for the first time.
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Remove the large cap from the canister.
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Slowly push the pump all the way down 5 times.

Do not use any EstroGel that came out while priming. Wash it down the sink to avoid accidental exposure to others.
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After priming, the pump is ready to use. One complete press of the pump will give the same amount of EstroGel each time.
See full Patient Information for complete priming and disposal instructions.

Applying EstroGel to Your Skin

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Do not allow other people to apply EstroGel to your skin for you.
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Apply EstroGel to clean, dry, unbroken skin.
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Apply EstroGel after your bath or shower.

If you go swimming, try to leave as much time as possible between using your EstroGel and going swimming.
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Remove the small cover on the tip of the pump if you have not done so already.
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To use EstroGel, press the pump firmly and fully 1 time into the palm of your hand.
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Using your hand, apply EstroGel to the skin of your other arm.

Spread the gel as thinly as possible over the entire area on the inside and outside of your arm from your wrist to your shoulder.
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Do not apply EstroGel directly to your breasts or in and around your vagina.
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Do not massage or rub in EstroGel.

Allow the gel to dry for up to 5 minutes before you get dressed.

After You Use EstroGel

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Place the small cap back on the tip of the pump. Place the large cap over the top of the canister.
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Wash your hands right away with soap and water after applying EstroGel.

This will lower the chance that the medicine will spread from your hands to other people.

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Do not allow others to make contact with the area of skin where you applied EstroGel for at least 1 hour after application.
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EstroGel is flammable until dry. Let EstroGel dry before smoking or going near an open flame.

Throwing Away Used EstroGel Canisters

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The EstroGel 50-gram canister contains enough medicine to allow for priming your canister with up to 5 full pump depressions and delivery of 30 daily doses.

After you have first primed your canister and used 30 doses, you will need to throw away the canister.

Do not use the canister for more than 30 doses, even though the canister may not be completely empty. You may not get the correct dose.

How to use: video demonstration

Click for EstroGel Patient Information, including full Instructions for Use.

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References: 1. EstroGel [package insert]. Herndon, VA: ASCEND Therapeutics; 2020.

Indication & Important Risk Information

EstroGel® 0.06% (estradiol gel) is approved by the FDA for use after menopause to reduce moderate to severe hot flashes and to treat moderate to severe menopausal changes in and around the vagina. If you use EstroGel only to treat your menopausal changes in and around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you.

WHAT IS THE MOST IMPORTANT RISK INFORMATION I SHOULD KNOW ABOUT EstroGel® (AN ESTROGEN HORMONE)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using EstroGel. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
  • Using estrogen-alone may increase your chances of getting strokes and blood clots.
  • Using estrogen-alone may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Do not use estrogens with progestins to prevent heart disease, heart attack, strokes or dementia.
  • Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
  • Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • You and your healthcare provider should talk regularly about whether you still need treatment with EstroGel.

Do not start using EstroGel if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack, currently have or have had blood clots, currently have or have had liver problems, have been diagnosed with a bleeding disorder, are allergic to EstroGel or any of its ingredients, or think you may be pregnant.

Tell your healthcare provider if you have any unusual vaginal bleeding, have any other medical conditions, are going to have surgery or will be on bed rest, are breastfeeding, and about all the medicines you take.

Serious but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus (womb), cancer of the ovary, high blood pressure, high blood glucose, gallbladder disease, liver problems, changes in your thyroid hormone levels, and enlargement of benign tumors (“fibroids”).

Common side effects of estrogens include headache, breast pain, stomach or abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection.

If you would like more information, talk with your healthcare provider. You may report side effects to ASCEND Therapeutics® US, LLC at 1-877-204-1013.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit , or call 1-800-FDA-1088.

Please see full Patient Information, including Boxed Warnings.

Indication & Important Risk Information

EstroGel® 0.06% (estradiol gel) is approved by the FDA for use after menopause to reduce moderate to severe hot flashes and to treat moderate to severe menopausal changes in and around the vagina. If you use EstroGel only to treat your menopausal changes in and around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you.

WHAT IS THE MOST IMPORTANT RISK INFORMATION I SHOULD KNOW ABOUT EstroGel® (AN ESTROGEN HORMONE)?

  • Using estrogen-alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using EstroGel. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogen-alone to prevent heart disease, heart attacks, strokes or dementia (decline in brain function).
  • Using estrogen-alone may increase your chances of getting strokes and blood clots.
  • Using estrogen-alone may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • Do not use estrogens with progestins to prevent heart disease, heart attack, strokes or dementia.
  • Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
  • Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older.
  • You and your healthcare provider should talk regularly about whether you still need treatment with EstroGel.

Do not start using EstroGel if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack, currently have or have had blood clots, currently have or have had liver problems, have been diagnosed with a bleeding disorder, are allergic to EstroGel or any of its ingredients, or think you may be pregnant.

Tell your healthcare provider if you have any unusual vaginal bleeding, have any other medical conditions, are going to have surgery or will be on bed rest, are breastfeeding, and about all the medicines you take.

Serious but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus (womb), cancer of the ovary, high blood pressure, high blood glucose, gallbladder disease, liver problems, changes in your thyroid hormone levels, and enlargement of benign tumors (“fibroids”).

Common side effects of estrogens include headache, breast pain, stomach or abdominal cramps, bloating, nausea and vomiting, hair loss, fluid retention, and vaginal yeast infection.

If you would like more information, talk with your healthcare provider. You may report side effects to ASCEND Therapeutics® US, LLC at 1-877-204-1013.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit , or call 1-800-FDA-1088.

Please see full Patient Information, including Boxed Warnings.