What is EstroGel?

EstroGel can help a woman manage some of her menopausal symptoms.

EstroGel provides

  • Effective relief of the following menopausal symptoms:1
    • Moderate to severe hot flashes
    • Moderate to severe dryness, itching, and burning in or around the vagina
  • Continuous relief from these menopausal symptoms with a low dose of estradiol1
  • An FDA-approved, bioidentical2 estrogen therapy available by prescription only

When menopause happens, life does not have to be put on hold. Symptoms of menopause can range from having hot flashes, and losing sleep because of night sweats to vaginal itching and dryness. While menopausal symptoms can interrupt your day, there’s no reason for them to change your life. Talk with your healthcare provider about a treatment that can help you maintain your lifestyle. EstroGel can help you manage your estrogen levels after menopause.

EstroGel is the #1 prescribed estrogen product in Europe and is approved to treat some menopausal symptoms in over 70 countries.3 Talk with your healthcare provider about EstroGel and join the other women already satisfied with their menopausal symptom relief.

Benefits of EstroGel

EstroGel offers a way to manage some of your menopausal symptoms. EstroGel is also convenient, non-messy to apply, and odorless when dry. This can help fit estrogen therapy into an active lifestyle, because EstroGel was designed for a modern woman.

Designed for a modern woman

  • EstroGel dosage is easy to remember—one pump, once per day1
  • EstroGel dries quickly to provide steady, continuous relief of symptoms
  • EstroGel goes on clear and is invisible and odorless once dry

Effective management with a bioidentical therapy

EstroGel can effectively manage your menopausal symptoms with a low dose of estradiol to help you maintain your active lifestyle. EstroGel is a bioidentical estrogen therapy derived from a plant source, an environmentally friendly source of estrogen appealing to an environmentally conscious woman.

EstroGel is an FDA-approved bioidentical estrogen therapy.1,2

  • The active ingredient in EstroGel is called estradiol, which is similar to the estrogen your body produces naturally1,2
  • EstroGel is plant based, and not made from an animal source3
  • EstroGel has proven symptom relief with a low dose of estradiol1 as recommended by the Women’s Health Initiative (WHI)
  • EstroGel is approved to treat some menopausal symptoms in over 70 countries3
  • EstroGel is the #1 prescribed estrogen product in Europe3
  • EstroGel is the #1 prescribed transdermal estrogen product in Canada3 


  • Estrogens increase the chance of getting cancer of the uterus (womb).

Report any unusual vaginal bleeding right away while you are using EstroGel. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find the cause.

  • Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia.

Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots.

Using estrogens, with or without progestins, may increase your risk of dementia, based on a study of women age 65 or older.  You and your healthcare provider should talk regularly about whether you still need treatment with EstroGel.

Do not start using EstroGel if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, currently have or have had liver problems, are allergic to EstroGel or any of its ingredients, or think you may be pregnant.

Tell your healthcare provider if you are breastfeeding, about all of your medical problems and medicines you take, and if you are going to have surgery or will be on bedrest.

Serious but less common side effects of estrogens include gallbladder disease, ovarian cancer, high blood pressure, liver problems, high blood sugar, and enlargement of benign tumors of the uterus (“fibroids”).

Common side effects of estrogens include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea, vomiting, hair loss, fluid retention, and vaginal yeast infection.

If you would like more information, talk with your healthcare provider or see full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

  1. EstroGel 0.06% (estradiol gel) [package insert]. Herndon, VA: ASCEND Therapeutics; 2008.
  2. Files JA, Ko MG, Pruhi S. Bioidentical hormone therapy. Mayo Clin Proc. 2011;86(7):673-680.
  3. Data on file, ASCEND Therapeutics.
  4. Simon JA, Mackowiak JI. Independent web-based vs “meaningful use” patient portals in assessing patient-reported outcomes: The estradiol gel 0.06% case study. SRM(supp.) October 2011;1-9.